tag:blogger.com,1999:blog-7684843.post5942716877750758786..comments2024-03-26T22:16:26.572-04:00Comments on Terrierman's Daily Dose: CRISPR PuppiesPBurnshttp://www.blogger.com/profile/05781540805883519064noreply@blogger.comBlogger6125tag:blogger.com,1999:blog-7684843.post-17512841320838077962017-08-13T20:43:18.516-04:002017-08-13T20:43:18.516-04:00Two wrongs could make a right. A wrong turn onto a...Two wrongs could make a right. A wrong turn onto a one way street followed by an illegal u turn. In situations like LUA in Dalmatians, where the problem is precisely known, simply reversing the problem is a good solution, and could sidestep (IMO stupid) breed purist objections to outcross/backcross approaches. Jenniferhttps://www.blogger.com/profile/14389321571689128858noreply@blogger.comtag:blogger.com,1999:blog-7684843.post-37505506321755262402017-08-11T02:36:24.839-04:002017-08-11T02:36:24.839-04:00Correct. LUA Dalmatians were bred 40 years ago by ...Correct. LUA Dalmatians were bred 40 years ago by Dr. SCHAIBLE, a geneticist, who used a Pointer as outcross to a breed without the gene responsible for HUA ( high uric acid) . As for deafness, to date no such gene has been found. Deafness is a stochastic event in dogs with the s/w, extreme white spotting allele.dphttps://www.blogger.com/profile/17744292896360465875noreply@blogger.comtag:blogger.com,1999:blog-7684843.post-57408771902565582522017-08-10T22:04:55.835-04:002017-08-10T22:04:55.835-04:00two wrongs don't make a right.
and hybridizat...two wrongs don't make a right.<br /><br />and hybridization and natural breeding in wild animals, or in plants, is not the same as genetically engineering. the procedures and the science are HUGELY different!tuffyhttps://www.blogger.com/profile/16113985064101042445noreply@blogger.comtag:blogger.com,1999:blog-7684843.post-62557555990628321232017-08-10T15:20:39.462-04:002017-08-10T15:20:39.462-04:00Yes, single gene mutation and all Dalmatians teste...Yes, single gene mutation and all Dalmatians tested were homozygous for that mutation; i.e. all were "affected" not carriers and not normal/unaffected (or "wild-type).<br /><br />Wild-type is used to describe PipedreamFarmhttps://www.blogger.com/profile/15689373141070251132noreply@blogger.comtag:blogger.com,1999:blog-7684843.post-54823095242299978272017-08-10T14:26:28.167-04:002017-08-10T14:26:28.167-04:00I **think** they have that with Dalmatians, which ...I **think** they have that with Dalmatians, which makes this interesting. See >> http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1000246 <br /><br />This is one of those rare cases where I believe a single gene mutation is the problem. But I do not understand it all and some simple words leave me cocked. For example, at the link above, what does "wild-type Golden Retriever" mean??PBurnshttps://www.blogger.com/profile/05781540805883519064noreply@blogger.comtag:blogger.com,1999:blog-7684843.post-75722892589496532632017-08-10T12:36:43.919-04:002017-08-10T12:36:43.919-04:00Crispr is of little use until the gene(s) responsi...Crispr is of little use until the gene(s) responsible for the phenotype have been located in the genomePipedreamFarmhttps://www.blogger.com/profile/15689373141070251132noreply@blogger.com